Onyx Scientific has expanded its solid form and material science screening capabilities following the company’s 25th anniversary at the end of 2025. The strategic investment strengthens early-phase and later-stage development services for complex molecules, including those in Developability Classification System (DCS) class II and IV categories.

The enhanced toolkit now includes the Technobis Crystalline PV/RR Line, which combines temperature and turbidity measurements with in-line particle imaging, enabling real-time visualisation down to 0.63 microns per pixel. Chris Atherton, commercial director at Onyx Scientific, said: “This investment is about moving faster and smarter. With added capacity for real-time particle insight, we can now guide clients with more confidence through early-phase material selection and optimization.”

The expansion builds on existing platforms including Crystal16 parallel screening, Radleys Mya Station, and Blaze probe technology, enhancing preformulation screening, design space refinement, and preparation of demonstration batches for internal evaluation and external partners.

In addition, Onyx has added three platforms for spray-drying, lyophilization, and jet milling to further tailor solid presentations for performance testing and accelerated development. These include:

• Buchi S300 mini spray dryer with inert loop and ultrasonic nozzle for amorphous solid dispersions and agglomeration studies.

• Buchi Lyovapor L-250 Pro supporting lyophilization from aqueous and organic systems.

• MC DecJet 30 jet mill for scalable micronization from milligrams to hundreds of grams, supporting inhalation and bioavailability applications.

Julian Northen, technical director at Onyx Scientific, said: “These tools allow us to deliver batches tailored for performance testing, both in-house and with our partner CROs and CMOs. Our clients often require small-scale, high-quality engineering batches to support PK, tox and FIH programs, and that’s exactly what this equipment enables.”

Together with particle imaging and measurement capabilities, Onyx can now prepare amorphous materials in multiple formats, optimise particle size, assess dissolution behaviour, and monitor amorphous content. Planned upgrades in early 2026 include enhancements to the XRPD suite, including non-ambient measurement capabilities, supporting internal upskilling, productivity improvements, and a long-term strategy to enhance solid-state development.

Northen added: “This is a continuation of our belief that robust material science underpins successful development. We’re strengthening our workbench, not just with tools, but with the expertise and insight to use them where they count.”