FairJourney Bio (FJBio) has expanded its portfolio with the launch of cryo-electron microscopy (cryo-EM) services, supported through its advanced laboratories in San Diego, USA. The offering provides high-resolution structural insights to support antibody discovery, selection, and biologic design.

The cryo-EM services utilise two ThermoFisher Titan Krios 5 systems and provide rapid, high-throughput analysis. Models can be delivered within 2–3 weeks of sample submission, supporting intermediate- and high-resolution validation of proteins, protein-protein, and protein-ligand complexes. The platform aims to provide high-quality, interpretable protein structures to inform decision-making throughout the antibody discovery and development process.

Tailored specifically for antibody discovery, the services support the R&D value chain across four stages: evaluation of epitope diversity in immune libraries, hit discovery using sequence-from-structure workflows, structure-informed lead selection, and computational protein design for next-generation synthetic libraries.

Dr. Werner Lanthaler, chief executive officer of FairJourney Bio, said: “Cryo-EM enables unique and powerful insights into molecular structures and interactions at an atomic level. Adding structure-based information from real-world images is a paradigm shift that allows researchers to de-risk their R&D projects along the entire value chain.

“The improved resolution removes guesswork at critical junctures in the R&D process and thus serves to both accelerate discovery projects as well as improving their success rates. FJBio’s cryo-EM platform with a dedicated team of experts is unmatched in terms of speed, scale and quality.”

Dr. Christopher Arthur, chief scientific officer Structural Biology, FairJourney Bio, added: “With the addition of cryo-EM services, supported by our high-end San Diego labs, we can provide our partners with the structural precision and expert support needed to accelerate the development of next-generation therapies.”