Carta Healthcare has secured $18.25 million in Series B1 financing to accelerate the adoption of its AI-powered platform for clinical data abstraction and analytics. The round, led by UPMC Enterprises, brings on new strategic investors from across the healthcare ecosystem, as health systems and life sciences companies increasingly turn to automation to transform data into actionable insight.

Joining UPMC Enterprises in the round were MemorialCare Innovation Fund, Rex Health Ventures (UNC Health’s investment arm), Tampa General Hospital Ventures, and returning investors including Memorial Hermann Health System, Frist Cressey Ventures, Storm Ventures, Paramark Ventures, CU Healthcare Innovation Fund, and Mass General Brigham Ventures.

UPMC, a longtime supporter of healthcare innovation, has backed Carta since its 2024 acquisition of Realyze Intelligence—an AI platform designed to match patients to clinical trials through analysis of structured and unstructured data.

“Health systems face growing challenges in clinical data abstraction and trial matching—tasks that are still largely manual and resource-intensive,” said Brent Burns, EVP at UPMC Enterprises.

“Carta’s platform automates these workflows, empowering clinicians with real-time insights to improve care. We’re excited to expand our partnership and explore broader deployment across UPMC.”

Carta’s flagship platform uses machine learning and deep clinical expertise to automate the collection and analysis of clinical data, helping organizations meet quality metrics, optimize trials, and reduce abstraction costs.

The company’s growth has been bolstered by its strong IP and integration into both health systems and life sciences workflows. In particular, demand is growing in the latter space following the integration of Realyze’s capabilities for trial matching.

Navid Farzad, managing partner at Frist Cressey Ventures, said the company’s strategy offers both clinical and financial returns. “Carta’s AI platform produces consistent, high-quality data while delivering immediate ROI by replacing labor-intensive abstraction processes,” he said.

Hospital investors also see a strategic fit. “Our goal is to support physicians and improve outcomes with smarter, digital-first tools,” said Feby Abraham, EVP and chief strategy officer at Memorial Hermann Health System. “Carta’s platform aligns with that mission and helps us care for our communities more efficiently.”

Founded in 2017, Carta Healthcare says its AI platform is already showing measurable impact across customer sites. CEO Brent Dover called the latest investment “a validation of our mission to get the right data into the right hands at the right time.”

“With strategic investors like UPMC and Memorial Hermann behind us, we can continue scaling to meet demand and push innovation in clinical operations and real-world evidence,” he said.

CFO Lucas Tanner added that the round reflects strong investor confidence in Carta’s fundamentals.

“We’ve seen consistent year-over-year growth,” he said. “This funding will support team expansion, operational scale, and deeper strategic partnerships. Our balance sheet is strong, and we’re positioned to lead in this emerging category.”